This house sign is placed at a Renaissance building in Erfurt, generally known as the Haus zum Stockfisch (House to the Stockfish). Present-day this edifice houses the municipal museum of Erfurt.
Interesting detail: The inscription is written in an old German.
‘Das Haus stehet in Gottes Hand zum Stockfisch ist genand’
The house is in God’s hand, it is named To The Stockfish’